Temozolomide (NSC 362856), DNA Alkylator
Por um escritor misterioso
Descrição
Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects. - Mechanism of Action & Protocol.
Imidazolecarboxamide - an overview
Current and future developments in the use of temozolomide for the treatment of brain tumours - The Lancet Oncology
Temozolomide 85622-93-1 wiki
Phase 1 trial of temozolomide plus irinotecan plus O6‐benzylguanine in adults with recurrent malignant glioma - Quinn - 2009 - Cancer - Wiley Online Library
Site specific DNA methylation with temozolomide. The main product of
Temozolomide Supplier, CAS 85622-93-1
Human Methyl Purine DNA Glycosylase and DNA Polymerase β Expression Collectively Predict Sensitivity to Temozolomide
DNA/RNA合成阻害 DNA/RNA Synthesis Inhibition
Variant allele frequency enrichment analysis in vitro reveals sonic hedgehog pathway to impede sustained temozolomide response in GBM
Temozolomide (NSC 362856), DNA Alkylator
Molecules, Free Full-Text
Table 1 from Preclinical antitumor activity of temozolomide in mice: efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea.
