Relative Selectivity of Covalent Inhibitors Requires Assessment of Inactivation Kinetics and Cellular Occupancy: A Case Study of Ibrutinib and Acalabrutinib
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Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK)
Sigmoidal correlation between Btk occupancy and experimentally observed
Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors - RSC Chemical Biology (RSC Publishing) DOI:10.1039/D0CB00033G
Relative Selectivity of Covalent Inhibitors Requires Assessment of Inactivation Kinetics and Cellular Occupancy: A Case Study of Ibrutinib and Acalabrutinib
Kinetic mechanisms of covalent inhibition - ScienceDirect
Proteomics and Beyond: Cell Decision-Making Shaped by Reactive Electrophiles: Trends in Biochemical Sciences
The Ascension of Targeted Covalent Inhibitors
Full article: Drug delivery targets and strategies to address mast cell diseases
Kinetic mechanisms of covalent inhibition - ScienceDirect
Structure-Function Relationships of Covalent and Non-Covalent BTK Inhibitors. - Abstract - Europe PMC
Pharmaceuticals, Free Full-Text
Haematologica, Volume 106, Issue 9 by Haematologica - Issuu
