Pharmaceutics, Free Full-Text
Por um escritor misterioso
Descrição
Viral and synthetic vectors to deliver nucleic acids were key to the rapid development of extraordinarily efficient COVID-19 vaccines. The four-component lipid nanoparticles (LNPs), containing phospholipids, PEG-conjugated lipids, cholesterol, and ionizable lipids, co-assembled with mRNA via a microfluidic technology, are the leading nonviral delivery vector used by BioNTech/Pfizer and Moderna to access COVID-19 mRNA vaccines. LNPs exhibit a statistical distribution of their four components when delivering mRNA. Here, we report a methodology that involves screening libraries to discover the molecular design principles required to realize organ-targeted mRNA delivery and mediate activity with a one-component ionizable multifunctional amphiphilic Janus dendrimer (IAJD) derived from plant phenolic acids. IAJDs co-assemble with mRNA into monodisperse dendrimersome nanoparticles (DNPs) with predictable dimensions, via the simple injection of their ethanol solution in a buffer. The precise location of the functional groups in one-component IAJDs demonstrated that the targeted organs, including the liver, spleen, lymph nodes, and lung, are selected based on the hydrophilic region, while activity is associated with the hydrophobic domain of IAJDs. These principles, and a mechanistic hypothesis to explain activity, simplify the synthesis of IAJDs, the assembly of DNPs, handling, and storage of vaccines, and reduce price, despite employing renewable plant starting materials. Using simple molecular design principles will lead to increased accessibility to a large diversity of mRNA-based vaccines and nanotherapeutics.
Pharmaceutics, Free Full-Text
RePub, Erasmus University Repository: Paediatric formulations : pharmaceutical development and clinical evaluation
Avicenna The Persian Gallen - Original Vintage Lithograph 1950s (history of pharmacy, medicine, medical, science, islam, islamic, iran)
Nitric Oxide Foundation - Berkeley Life Professional
Eniva Health Creatine Monohydrate Powder, Amino Acid, Micronized Powder, 70 Servings 5 G 12.3 oz, Muscle Support, Muscle Growth, Cellular Energy, Cognitive Focus, Ultra-Pure, Pharmaceutical Grade : Health & Household
Dota 6.64 Ai Plus - Colaboratory
Pharmaceutics, Free Full-Text
PDF] Obtaining and providing health information in the community pharmacy setting.
Overcoming Barriers to Pharma Market Access in Emerging Markets, Request a FREE Proposal From Infiniti's Pharma Industry Experts for Detailed Insights
West Pharmaceutical Services Full Year 2022 Earnings: Revenues Beat Expectations, EPS Lags
